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Biochemistry

SARS-Cov2 IgG Antibodies (Abbott)

Reference Range

Negative - No evidence of antibody response to SARS-CoV-2. This can indicate
no COVID-19 infection, very early infection, or infection in the
context of immunosupression.
An increase in antibody level can support a diagnosis of Covid-19.
Consider repeat testing in 14 days if confirmation of infection or exposure to COVID 19 is suspected

Any result should not affect compliance with personal
protection guidelines.

Equivocal - SARS-CoV-2 IgG antibodies: Equivocal by EIA (Abbott)
Inconclusive result, which may occur early in the infection or
could be non-specific.
An increase in antibody level can support a diagnosis of Covid-19.
Consider repeat testing in 14 days if confirmation of infection or exposure to COVID 19 is suspected

Any result should not affect compliance with personal
protection guidelines.

Positive - SARS-CoV-2 IgG antibodies: Positive by EIA (Abbott)
Consistent with current or previous Covid-19 infection.
Please Note result DOES NOT indicate immunity from future
infection or prevent current or future excretion of the
virus (infectivity).

Any result should not affect compliance with personal
protection guidelines.

Turnaround Time: 24 hrs from receipt

Creatine Kinase (CK)

Reference Range

Females 29 - 168 U/L

Males 30 - 200 U/L

CK levels are higher in males than in females, and in black race populations. Exercise, muscle trauma (contact sports, traffic accidents, intramuscular injections, surgery, convulsions, wasp or bee stings, and burns), and drugs such as cholesterol-lowering statins can damage muscle and increase serum CK concentrations.

Turnaround Time: 1 day

Creatinine

Reference Range

Adult Male: 64-104 µmol/L

Adult Female: 49 - 90 µmol/L

Turnaround Time: 1 day

Related Tests Potassium (serum) Sodium Urea (Serum)

Creatinine (Urine)

Reference Range

Male: 9.0-18.0 mmol/24hrs

Female: 7.0-16.0 mmol/24hrs

Turnaround Time: 1 day

Renin

Reference Range

From 1/3/18 renin samples are analysed using the IDS iSYS direct renin mass immunoassay which will use the following reference ranges:

Ambulatory: Female: 6.1 – 62.7 mIU/L, Male: 9.0 – 103 mIU/L

Supine: 4.2 – 59.7 mIU/L

Screen positive for Conns: Aldosterone/renin ratio >91pmol/mU + aldosterone >750 pmol/L

(Endocrine guidelines on the investigation of Conns https://doi.org/10.1210/jc.2015-4061)

The Aldosterone/Renin ratio cut-off that we are providing is a guide only and not a diagnostic test and the ratio should be interpreted, cautiously, in conjunction with relevant clinical information and medications that may affect the ratio.

Turnaround Time: 5 working days

Creatinine Clearance

Reference Range

Adult male/female reference range: ≥90 mL/min

(2014 NICE CKD guidelines CG182)

Turnaround Time: 24 Hours

Related Tests Creatinine Creatinine (Urine)

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Location of UHB Laboratories

Protection of Personal Information – Clinical Laboratory Services comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

Molecular Pathology is a UKAS accredited medical laboratory No. 8759
Biochemistry is a UKAS accredited medical laboratory No. 8910
Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
Cellular Pathology is a UKAS accredited medical laboratory No. 10141
Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962