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Biochemistry

Lactate

Reference Range

<16yrs 0.6-2.5 mmol/L (Source : Pathology Harmony Recommendations)

Adult 0.5-2.2 mmol/L (Source : Abbott Diagnostics)

CSF lactate-age related: 1.1-6.7mmol/L (neonates) 1.1-2.4 mmol/L (adults)

Turnaround Time: 1 day

Theophylline

Reference Range

Therapeutic range: 10-20 mg/L (Pre-dose)

Minimum time for patient to reach steady state without loading or after dosage change is 2 days

Turnaround Time: 24 hours

Thiopurine S-Methyltransferase (TPMT)

Reference Range

TPMT phenotype/activity reference ranges:

<6 nmol/ghb/hr = Deficient
6-34 nmol/gHb/hr = Low
35-79 nmol/gHb/hr = Normal
>79 nmol/gHb/hr = High

TPMT genotype classifications:

WT = wild-type, normal result
H3 = TPMT 1*/3* - heterozygous for TPMT, this would indicate a reduced activity. Advise reduce dose of azothioprine.
H2 = TPMT 1*/2* - heterozygous for TPMT, this would indicate a reduced activity. Advise reduce dose of azothioprine
H03 = TPMT 3*/3* - homozygous for TPMT, this would indicated deficient TPMT activity. Advise stop treatment with azothioprine.
H02 = TPMT 2*/2* - homozygous for TPMT, this would indicated deficient TPMT activity. Advise stop treatment with azothioprine.

Turnaround Time: 14 days

Thyroglobulin

Reference Range

No reference ranges applicable. Results must be interpreted with Thyroglobulin antibodies.

Successfully treated post-thyroidectomy patients should have an undetectable serum thyroglobulin. Elevations in Thyroglobulin post-thyroidectomy for differentiated thyroid cancer can indicate recurrence of disease or metastasis. Thyroglobulin analysis is most sensitive when TSH is not suppressed i.e. any small thyroid remnants of disease present should produce measurable Thyroglobulin.

Interpretation of results also depends on factors such as whether the patient is on T4/T3 replacement.

Higher levels may be seen in the newborns and in the third trimester of pregnancy.

Benign elevations of Thyroglobulin see with:

Grave's disease
Hashimoto's disease
Adenomas

Turnaround Time: 2 days for immunometric assay (TgIMA), 2 - 3 weeks for RIA assay (TgRIA)

Thyrotrophin (TSH)

Reference Range

Adult reference range = 0.40-4.90 mIU/L

Turnaround Time: 1 day

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University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

Molecular Pathology is a UKAS accredited medical laboratory No. 8759
Biochemistry is a UKAS accredited medical laboratory No. 8910
Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
Cellular Pathology is a UKAS accredited medical laboratory No. 10141
Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962