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Haematology

Haematology Referred Work (10)

Thrombin Time

Thrombin Time

Reference Range

0.8-1.2

  • Turnaround Time: 24 hours
Anti-Xa Assay

Anti-Xa Assay

Reference Range

LMWH:

Prophylactic Reference Range 0.1-0.3 IU/mL

Therapeutic Range 0.5-1.0 IU/mL

Therapeutic range for mechanical heart valve during pregnancy 1.0-1.4 IU/mL

Rivaroxaban:

Stroke prevention in NVAF 20mg OD 184-343ng/mL[1]

Treatment of PE/DVT 20mg OD 189-419ng/mL[1]

Treatment of PE/DVT 10mg OD 7-273ng/mL[2]

Treatment of ACS 2.5mg OD 13-123ng/mL[2]

Apixaban:

Stroke prevention in NVAF 5mg BD 91-321ng/mL[1]

Stroke prevention in NVAF 2.5mg BD 69-221ng/mL[2]

Treatment of PE/DVT 10mg BD 111-572ng/mL[2]

Treatment of PE/DVT 5mg BD 59-302ng/mL[1]

Treatment of PE/DVT 2.5mg BD 30-153ng/mL[2]

Fondaparinux:

2.5mg OD 0.39-0.50ug/mL[1]

7.5mg OD 1.20-1.26ug/ml[1]

Edoxaban:

Stroke prevention in NVAF 60mg OD 125-245ng/mL[1]

Treatment of PE/DVT 60mg OD 149-317ng/mL[1]

Stroke prevention in NVAF 30mg OD 55-120ng/mL[2]

Treatment of PE/DVT 30mg OD 99-125ng/mL[2]

 

[1] Measurement of heparin, direct oral anti-coagulants and other non-coumarin anti-coagulants and their effects on haemostasis assays: A British Society for Haematology Guideline, Baker et al, Brit J Haematol, 2024

[2] Update of the International Council for Standardization in Haematology Recommendations for Laboratory Measurement of Direct Oral Anticoagulant, Douxfils et al, Thromb Haemost, 2021

  • Turnaround Time: 7 days (Unless urgent by prior arrangement with laboratory)
Factor Assay

Factor Assay

Reference Range

FII (Factor 2) 87-129 u/dL

FV (Factor 5) 66-135 u/dL

FVII (Factor 7) 66-170 u/dL

FVIII (Factor 8) 57-158 u/dL

FIX (Factor 9) 82-166 u/dL

FX (Factor 10) 76-171 u/dL

FXI (Factor 11) 70-164 u/dL

FXII (Factor 12) 64-183 u/dL

Bovine Chromogenic FVIII (Factor 8) 0.67-1.44 IU/ml

  • Turnaround Time: 7 days (Unless urgent by prior arrangement with laboratory)
Von Willebrand Screen

Von Willebrand Screen

Reference Range

Factor VIII 57-158 u/dL

von Willebrand Factor Antigen (VWF:Ag) 48-175 u/dL

von Willebrand Factor Activity (VWF:RCo, RICOF) 47-154 u/dL

von Willebrand Factor Collagen Binding activity (vWF:CBA) 57-164 IU/dL

  • Turnaround Time: 7 days (Unless urgent by prior arrangement with laboratory)
ADAMTS13 Activity / Inhibitor (IgG)

ADAMTS13 Activity / Inhibitor (IgG)

Reference Range

Reference Ranges are dependent upon methodology:

ADAMTS13 Activity:

ACUSTAR (primary method): 62-118 IU/dL

ELISA (secondary method, used for confirmatory check of equivocal results): 38-110%

ADAMTS13 inhibitor (IgG):

Neg <12 U/mL

Borderline 12-15 U/mL

Positive >15 U/mL

  • Turnaround Time: ADAMTS13 Activity: 6 hours for urgent requests, 7 days for routine requests, ADAMTS13 Inhibitor: 21 days.
Heparin Induced Thrombocytopenia Screen (HIT)

Heparin Induced Thrombocytopenia Screen (HIT)

Reference Range

Reference Ranges are dependent upon methodology:

ACUSTAR (primary method): 0-0.99 U/ml. HIT cannot be excluded for results => 1.0 U/ml

HIT ELISA (secondary method, used for VITT cases): >0.4-1.0 weak positive, >1.0 Positive

  • Turnaround Time: 7 days (Unless urgent by prior arrangement with laboratory)
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Copyright UHB Pathology 2025

Protection of Personal Information – Pathology Laboratories Services comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. Laboratories are currently transitioning across to ISO 15189:2022 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/ 

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • United Kingdom Health Security Agency laboratory is a UKAS accredited medical laboratory No.8213

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: https://qehbpathology.uk/test-database 

For further information contact Louise Fallon, Quality Manager, 0121 371 5962/ 0121 424 1235