Preferred Sample Type

Emicizumab Assay

Suitable Specimen Types

Citrated Plasma

Emicizumab Assay

Specimen Volume

2 x 3.5 mL

Specimen Transport

Standard transport to laboratory - State for the attention of Special Coagulation on request form

Sample Preparation

Samples for any coagulation tests must be filled to the black fill line indicated on the sample tube. Any sample filled above or below this level will be rejected and a repeat sample will be required

Turnaround Time

21 days

Sample Processing In Laboratory

Sample should be centrifuged

Sample Stability

12 hours from venepuncture (ideally received no later than 4 hours after collection)

General Information

Samples that meet the following criteria will not be processed:

  • Haemolysed, clotted, underfilled or overfilled samples.
  • Samples >12 hours old from the time of collection.
  • Samples received from other hospital laboratories that have been frozen and thawed.
  • Samples which fail the minimum data set.

Assay limitations:

  • FVIII concentrate replacement products present in patient samples may cause an elevation in emicizumab concentrations using the modified one-stage assay.

Reference Range

Therapeutic range: 40-60µg/ml

Specifications

  • EQAS Scheme: No

General Information

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Location of Laboratories

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