Preferred Sample Type
Suitable Specimen Types
CSFTotal Protein (CSF)
Specimen Volume
1 mL minimumTurnaround Time
1 day
Sample Processing In Laboratory
UsualSample Stability
Stable for 1 day at 15°C to 25°C, 6 days at 2°C to 8°C. Stable for >1 year at -15°C to -25°C
General Information
Most CSF protein originates by diffusion from plasma across the blood-CSF barrier. Elevated levels of protein occur as a result of increased permeability of the blood-CSF barrier or with increased local synthesis of immunoglobulins. Examination of CSF is most often performed in the investigation of suspected meningitis. In meningitis there is secretion of IgG into the CSF but this has little effect on the total amount of protein. However, meningeal inflammation may lead to an increase in capillary permeability and a marked increase in CSF protein content.
Patient Preparation
None
Notes
Interference from haemolysis.
Reference Range
0.15 - 0.40 g/L
Source of Reference Range
Manuracturer's test information sheet
Specifications
- EQA Status: IMMQAS