Biochemistry

Preferred Sample Type

Total Protein (CSF)

Suitable Specimen Types

CSF

Total Protein (CSF)

Specimen Volume

1 mL minimum

Turnaround Time

1 day

Sample Processing In Laboratory

Usual

Sample Stability

Stable for 1 day at 15°C to 25°C, 6 days at 2°C to 8°C. Stable for >1 year at -15°C to -25°C

General Information

Most CSF protein originates by diffusion from plasma across the blood-CSF barrier. Elevated levels of protein occur as a result of increased permeability of the blood-CSF barrier or with increased local synthesis of immunoglobulins. Examination of CSF is most often performed in the investigation of suspected meningitis. In meningitis there is secretion of IgG into the CSF but this has little effect on the total amount of protein. However, meningeal inflammation may lead to an increase in capillary permeability and a marked increase in CSF protein content.

 

 

Patient Preparation

None

Notes

Interference from haemolysis.

 

Reference Range

0.15 - 0.40 g/L

Source of Reference Range

Manuracturer's test information sheet

Specifications

  • EQA Status: IMMQAS

Link to Further Information

Centrifuge all samples at 3200 rpm for 10 minutes prior to analysis.

Related Tests

Bilirubin (Total) CSF Xanthochromia Glucose (CSF)

Creation Date

Monday, 08 August 2011

Modification Date

Tuesday, 10 March 2020

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Protection of Personal Information – Clinical Laboratory Services comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962