Preferred Sample Type
Suitable Specimen Types
FaecesCalprotectin (faecal)
Specimen Volume
1 - 5g faecesSpecimen Transport
Usual to laboratoryTurnaround Time
7 working daysSample Stability
Sample and extract can be stored at 4oC for one weekGeneral Information
Calprotectin is a protein found in cells involved in inflammation. It is present in abundance in neutrophils. The concentration of calprotectin in faeces is increased in inflammatory bowel disease and has been shown to be a better marker of the disease activity (seen on tissue biopsy) than blood test markers of inflammation (e.g. white blood cell count, ESR and CRP). Its measurement is relatively cheap, non-invasive and it is stable in faeces at room temperature for several days.
The main diseases that cause an increased excretion of faecal calprotectin are Crohn's disease, ulcerative colitis and cancer. Levels of faecal calprotectin are not raised in patients with irritable bowel syndrome (IBS).
Patient Preparation
Random faecal sample (any time of day, no dietary restrictions required) in a plain universal container and approximately 1 gram in weight. Ideally stool should be formed and not contain mucous.
Notes
Calprotectin testing should follow the CCG guidelines.
Reference Range
<60 µg/g – Normal calprotectin. No evidence of GI inflammation - ?IBS
60-150 µg/g – Borderline raised calprotectin indicating mild inflammation. Stop any NSAIDs and repeat in 4 weeks
>150 µg/g – Raised calprotectin. This may indicate inflammatory bowel disease. Refer to gastroenterology
Specifications
- EQA Status: NEQAS
- EQAS Scheme: Yes