Biochemistry

Preferred Sample Type

Alpha-1-Antitrypsin (A1AT or AAT) Phenotyping

Suitable Specimen Types

Serum

Alpha-1-Antitrypsin (A1AT or AAT) Phenotyping

Specimen Volume

1 mL

Sample Preparation

Samples must be clot-free, should not be haemolysed and should be free of any other particles.

Turnaround Time

14 days

Sample Processing In Laboratory

Usual

Sample Stability

Store at 2-8°C

General Information

Some indications: Indicated where A1AT levels are below median for age. Alpha 1 antitrypsin deficiency is associated with liver disease and pulmonary emphysema. A1AT is a glycoprotein and a part of a family of protease inhibitors that control various inflammatory cascades. Genetic variants of A1AT are characterisedby their different electrophoretic mobilties i.e. M, S or Z. Z and S variants have decreased synthesis of A1AT. S forms produce 60-80% of normal and Z produces only 15% of normal.Normal range is age related.

Patient Preparation

None

Reference Range

M pattern

Specifications

  • EQA Status: IMMQAS
  • EQAS Scheme: Yes

Creation Date

Monday, 08 August 2011

Modification Date

Wednesday, 09 November 2022

General Information

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Protection of Personal Information – Clinical Laboratory Services comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962