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Categories starting with T

Toxicology (2)

Items starting with T

Testosterone

Testosterone

Reference Range

Adults:

Female: <1.9 nmol/L

Male: 7.0-27.0 nmol/L

Paediatrics:

Female Tanner stage 1: <0.6 nmol/L

Male Tanner stage 1: <0.7 nmol/L

  • Turnaround Time: 72 hours

Related Tests Follicle Stimulating Hormone (FSH) Luteinising Hormone (LH)

Theophylline

Theophylline

Reference Range

Therapeutic range: 10-20 mg/L (Pre-dose)

  • Minimum time for patient to reach steady state without loading or after dosage change is 2 days
  • Turnaround Time: 24 hours
Thiopurine S-Methyltransferase (TPMT)

Thiopurine S-Methyltransferase (TPMT)

Reference Range

 

TPMT phenotype/activity reference ranges:

  • <6 nmol/ghb/hr = Deficient
  • 6-34 nmol/gHb/hr = Low
  • 35-79 nmol/gHb/hr = Normal
  • >79 nmol/gHb/hr = High

TPMT genotype classifications:

  • WT = wild-type, normal result
  • H3 = TPMT 1*/3* - heterozygous for TPMT, this would indicate a reduced activity.  Advise reduce dose of azothioprine.
  • H2 = TPMT 1*/2* - heterozygous for TPMT, this would indicate a reduced activity.  Advise reduce dose of azothioprine
  • H03 = TPMT 3*/3* - homozygous for TPMT, this would indicated deficient TPMT activity.  Advise stop treatment with azothioprine.
  • H02 = TPMT 2*/2* - homozygous for TPMT, this would indicated deficient TPMT activity.  Advise stop treatment with azothioprine.
  • Turnaround Time: 14 days
Thrombin Time

Thrombin Time

Reference Range

0.8-1.2

  • Turnaround Time: 24 hours
Thrombophilia Screen

Thrombophilia Screen

Reference Range

Antithrombin function (AT) 83-127 u/dL

Protein C function 65-171 u/dL

Protein S Antigen (Free Protein S) Male: 75-139 u/dL, Female: 55-125 u/dL

Lupus Anticoagulant Screen - Please see report (reagent batch dependant)

Factor V Leiden mutation - Absent

Prothrombin gene 20210A mutation - Absent

  • Turnaround Time: 21 days

Thyroglobulin

Reference Range

No reference ranges applicable. Results must be interpreted with Tg antibodies. Tg analysis is most sensitive when TSH is not suppressed (>30 mIU/L) i.e. any small thyroid remnants of disease present should produce measurable Tg

Elevations in Tg post-thyroidectomy for differentiated thyroid cancer can indicate recurrence of disease or metastasis

Interpretation of results also depends on factors such as whether the patient is on T4/T3 replacement.

The limit of detection of the assay is < 5 ug/L.

Higher levels may be seen in the newborn and in the third trimester of pregnancy.

Benign elevations:

  • Grave's
  • Hashimoto's
  • Adenoma

References

British Thyroid Association & Royal College of Physicians, Thyroid Cancer Guidelines 2007

Spencer et al., 2005. Clinical Impact of Tg and TgAb Method Differences on the Management of Patients with Differentiated Thyroid Carcinomas. J Clin Endocrinol Metab 90:5566-5575

   

 

  • Turnaround Time: 10 days

Related Tests Free T4 (FT4) Thyroxine Free Triodothyronine (FT3) Thyrotrophin (TSH)

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Protection of Personal Information – Clinical Laboratory Services comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962