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Categories starting with T

Items starting with T

Testosterone

Testosterone

Reference Range

Adults:

Female: <1.9 nmol/L

Male: 7.0-27.0 nmol/L

Paediatrics:

Female Tanner stage 1: <0.6 nmol/L

Male Tanner stage 1: <0.7 nmol/L

  • Turnaround Time: 72 hours
Theophylline

Theophylline

Reference Range

Therapeutic range: 10-20 mg/L (Pre-dose)

  • Minimum time for patient to reach steady state without loading or after dosage change is 2 days
  • Turnaround Time: 24 hours
Thiopurine S-Methyltransferase (TPMT)

Thiopurine S-Methyltransferase (TPMT)

Reference Range

 

TPMT phenotype/activity reference ranges:

  • <6 nmol/ghb/hr = Deficient
  • 6-34 nmol/gHb/hr = Low
  • 35-79 nmol/gHb/hr = Normal
  • >79 nmol/gHb/hr = High

TPMT genotype classifications:

  • WT = wild-type, normal result
  • H3 = TPMT 1*/3* - heterozygous for TPMT, this would indicate a reduced activity.  Advise reduce dose of azothioprine.
  • H2 = TPMT 1*/2* - heterozygous for TPMT, this would indicate a reduced activity.  Advise reduce dose of azothioprine
  • H03 = TPMT 3*/3* - homozygous for TPMT, this would indicated deficient TPMT activity.  Advise stop treatment with azothioprine.
  • H02 = TPMT 2*/2* - homozygous for TPMT, this would indicated deficient TPMT activity.  Advise stop treatment with azothioprine.
  • Turnaround Time: 14 days
Thrombin Time

Thrombin Time

Reference Range

0.8-1.2

  • Turnaround Time: 24 hours
Thrombophilia Screen

Thrombophilia Screen

Reference Range

Antithrombin function (AT) 83-127 u/dL

Protein C function 65-171 u/dL

Protein S Antigen (Free Protein S) Male: 75-139 u/dL, Female: 55-125 u/dL

Lupus Anticoagulant Screen - Please see report (reagent batch dependant)

Factor V Leiden mutation - Absent

Prothrombin gene 20210A mutation - Absent

  • Turnaround Time: 21 days

Thyroglobulin

Reference Range

No reference ranges applicable. Results must be interpreted with Tg antibodies. Tg analysis is most sensitive when TSH is not suppressed (>30 mIU/L) i.e. any small thyroid remnants of disease present should produce measurable Tg

Elevations in Tg post-thyroidectomy for differentiated thyroid cancer can indicate recurrence of disease or metastasis

Interpretation of results also depends on factors such as whether the patient is on T4/T3 replacement.

The limit of detection of the assay is < 5 ug/L.

Higher levels may be seen in the newborn and in the third trimester of pregnancy.

Benign elevations:

  • Grave's
  • Hashimoto's
  • Adenoma

References

British Thyroid Association & Royal College of Physicians, Thyroid Cancer Guidelines 2007

Spencer et al., 2005. Clinical Impact of Tg and TgAb Method Differences on the Management of Patients with Differentiated Thyroid Carcinomas. J Clin Endocrinol Metab 90:5566-5575

   

 

  • Turnaround Time: 10 days
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