Biochemistry

Preferred Sample Type

Alkaline Phosphatase (ALP) Isoenzymes (APISO)

Suitable Specimen Types

Special Collection Procedures Apply

Alkaline Phosphatase (ALP) Isoenzymes (APISO)

Specimen Volume

1.0mL blood

Specimen Transport

Not applicable

Sample Preparation

Serum only accepted (yellow or red top).

Turnaround Time

4 weeks

Sample Processing In Laboratory

Centrifuge and separate serum. Perform total ALP analysis and GGT analysis beforehand and store sample at -20°C.

Sample Stability

Store at -20°C

General Information

Alkaline Phosphatases (ALP) form a group of non-specific enzymes that hydrolyse a wide variety of ester orthophosphates under alkaline conditions. The total alkaline phosphatase activity represents several molecular forms or isoenzymes derived from a variety of human tissue sources.  The biliary canaliculi of the liver, osteoblasts of bone, intesti­nal mucosa and the placenta are sources of alkaline phosphatase isoenzymes.  Addi­tional isoenzymes are associated with specific benign and malignant disord­ers.  

An elevated total serum alkaline phosphatase is often one of the first biochemical abnormalities to be encountered in clinical investigation. Assessment of the isoen­zyme fractions contributing to the elevated value gives valuable information in a va­riety of clinical conditions, such as hepatobiliary disease and bone disease.

Patient Preparation

No specific patient preparation is required for this test. The test can only be performed in serum (yellow or red top).

 

 

Reference Range

A qualitative report is provided. Reference range is not applicable.

 

Source of Reference Range

Not applicable

Specifications

  • EQA Status: No EQA scheme available.
  • EQAS Scheme: No

Related Tests

Alkaline Phosphatase (ALP)

Creation Date

Monday, 08 August 2011

Modification Date

Thursday, 17 May 2018

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University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962