Preferred Sample Type

Serum Uric Acid (Urate)

Suitable Specimen Types


Serum Uric Acid (Urate)

Specimen Volume

1 mL blood

Sample Preparation


Turnaround Time

1 day

Sample Processing In Laboratory


Sample Stability

5 days at 2 to 8°C

General Information

Uric acid (urate) is the final metabolite of endogenous and dietary purine nucleotide metabolism. It is the product of xanthine oxidase–catalyzed conversion of xanthine and hypoxanthine.

Hyperuricaemia may occur due to increased formation of uric acid due to primary causes such as inherited metabolic diseases or secondary causes such as increased intake, increased nucleic acid turnover (e.g. in leukemia, myeloma or chemotherapy) or tissue hypoxia. It may also occur due to decreased excretion due to AKI, CKD or preeclampsia. Asymptomatic hyperuricaemia is frequently detected via biochemical screening. Long-term follow up of these patients should be undertaken because many are at risk of kidney disease as a result of hyperuricaemia and hyperuricuria. Few of these patients ever develop the clinical symptoms of gout, a systemic disease caused by the buildup of uric acid in the joints

Hypouricaemia is much less common than hyperuricaemia and may be due to severe hepatocellular disease, defective renal tubular absorption of uric acid (e.g. in Fanconi syndrome) or over-treatment with allopurinol, 6-mercaptopurine or azothioprine. Very rarely hypoyricaemia may be to an inherited metabolic defect, such as those which cause a xanthine oxidase deficiency.

Urinary uric acid measurement, together with serum uric acid, should be perfored in stone formers as hyperuricuria is a risk factor for the formation of both uric acid stones and calcium stones.

Patient Preparation


Reference Range

Males: 210-420 µmol/L

Females: 150-350 µmol/L


  • EQA Status:


  • EQAS Scheme: Yes

General Information

General information about the website and its content

Location of Laboratories

Where the laboratories are located and information about the services offered at each laboratory