Biochemistry

Preferred Sample Type

Troponin I - High Sensitive

Suitable Specimen Types

Serum

Troponin I - High Sensitive

Specimen Volume

250 uL

Sample Preparation

Centrifuge

Stability : 72 hours at 2-8°C

12 months at -20°C (freeze only once).


Turnaround Time

1 hour (urgent pathway)

Sample Processing In Laboratory

Urgent

Sample Stability

24 hours Room Temperature, 72 hours 2-8 degrees Celsius, store at -20 degrees Celsius for longer storage.

General Information

Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

Patient Preparation

None

Reference Range

The cut-off values used for the Abbott Alinity Troponin I assay are based 99th percentiles and are as below:


• Male <34 ng/L
• Female <16 ng/L

 

 

Source of Reference Range

Manufacturer's kit insert (Abbott Alinity)

Specifications

  • EQA Status:

    UK NEQAS cardiac markers

  • EQAS Scheme: Yes

Link to Further Information

Investigation flow chart

Creation Date

Monday, 08 August 2011

Modification Date

Monday, 18 July 2022

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University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962