Biochemistry

Preferred Sample Type

Creatinine (Urine)

Suitable Specimen Types

Plain Spot Urine 24 Hour Urine Plain

Creatinine (Urine)

Specimen Volume

24 hour urine collection or random collection (minimum sample volume 500 uL)

Sample Preparation

Usual

Turnaround Time

1 day

Sample Processing In Laboratory

Usual

Sample Stability

Samples are stable for seven days at 4 ºC, freeze samples at -20 ºC for long term storage.

General Information

Creatinine is a non-protein waste product of creatine phosphate metabolism by skeletal muscle tissue. Creatinine production is continuous and is proportional to muscle mass. Serum creatinine concentrations are used in the determination of creatinine clearance (an indicator of GFR) and estimation of the GFR utilising the 4 variable MDRD equation. Each of these derived figures can then be used to both identify and monitor chronic kidney disease. Determination of urine creatinine is useful in:

  • The measurement of creatinine clearance which also requires measurement of creatinine in serum. (Requires 24 hour urine collection)
  • Determination of the albumin/creatinine ratio (ACR) in testing for microalbuminuria (requires plain spot urine)
  • To compensate for variations in urine concentration in spot-check and 24 hour samples, it is helpful to compare the amount of the analyte of interest to its concentration of creatinine

Patient Preparation

None

Notes

Estimation of creatinine clearance requires a 24 hour urine sample and paired serum creatinine sample.

Reference Range

Male:  9.0-18.0 mmol/24hrs

Female:  7.0-16.0 mmol/24hrs

 

Specifications

  • EQA Status: NEQAS
  • EQAS Scheme: Yes

Link to Further Information

https://pinboard.in/u:duty_biochemist/t:Creatinine/

Related Tests

Albumin (Urine) (microalbumin ACR) Creatinine Creatinine Clearance Urine Protein:Creatinine ratio (Random urine)

Creation Date

Monday, 08 August 2011

Modification Date

Wednesday, 23 May 2018

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Protection of Personal Information – Clinical Laboratory Services comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962