Biochemistry

Preferred Sample Type

Angiotensin Converting Enzyme (ACE)

Suitable Specimen Types

Special Collection Procedures Apply

Angiotensin Converting Enzyme (ACE)

Specimen Volume

1 mL blood

Specimen Transport

Not applicable

Sample Preparation

Centrifuge

Turnaround Time

7 days

Sample Processing In Laboratory

No special requirements

Sample Stability

Stable for 30 days at 2-8°C and six months at -20 ºC.

General Information

Elevated levels of ACE occur in the serum of patients with active sarcoidosis, tuberculosis, Gaucher's (a lysosomal storage disease), leprosy, many other pathologic conditions including lung and liver disease, and occasionally in premature infants with respiratory distress syndrome. ACE levels are also raised in hyperthyroidism.

 

In 40 to 60% of patients with sarcoidosis, ACE activity is increased. However, a single ACE measurement does not necessarily predict the presence or extent of lung injury.  The main clinical use of ACE measurements is of serial levels in therapeutic monitoring and as a warning of possible relapse.

Patient Preparation

None

 

 

Notes

Do not use EDTA plasma as EDTA inhibits ACE activity. Serum (yellow top/red top) is the only suitable sample type for this assay.

Haemolysis, lipaemia and jaundice interfere

Reference Range

 

Adults:               20-70 IU/L

(Source: Buhlmann Laboratories)

Serum levels in individuals under 18 years of age are substantially higher and more variable than in adults.

 

Source of Reference Range

Buhlmann laboratories

Specifications

  • EQA Status: WEQAS
  • EQAS Scheme: Yes

Link to Further Information

http://www.labtestsonline.org.uk/understanding/analytes/ace/

Related Tests

Calcium (adjusted)

Creation Date

Monday, 08 August 2011

Modification Date

Thursday, 17 May 2018

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University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962