Biochemistry

Preferred Sample Type

Phosphate (Urine)

Suitable Specimen Types

24 Hour Urine (Acid Collection)

Phosphate (Urine)

Sample Preparation

Urine time and volume should be recorded on the form

Turnaround Time

1 day

Sample Processing In Laboratory

Usual

Sample Stability

Usual

General Information

Urinary phosphate analysis is useful in the differential diagnosis of hypo and hyperphosphataemia.

Hypophosphataemia with a low urinary excretion (i.e. <3 mmol="" 24h="" of="" phosphate="" is="" most="" likely="" due="" to="" decreased="" intake="" increased="" cell="" uptake="" or="" loss="" from="" the="" gut="" a="" high="" urinary="" excretion="" i="" e="">3 mmol/24hr> is associated with renal loss and together with a high plasma calcium concentration can be attributed to primary hyperparathyroidism or malignancy. A high urinary excretion with a normal or low plasma calcium implies secondary hyperparathyroidism, vitamin D deficiency, Fanconi syndrome, hypomagnesaemia, diuretic therapy or oncogenic osteomalacia.

Hyperphosphataemia with a urinary excretion of <50 mmol="" 24h="" is="" suggestive="" of="" hypoparathyroidism="" whereas="" a="" level="">50 mmol/24h suggests increased intake, cell destruction or bone malignancy. Other causes of hyperphosphataemia (e.g. renal failure, vitamin D toxicity, DKA & lactic acidosis) may be exluded using plasma creatinine or calcium measurements.

 

Patient Preparation

None

Reference Range

15-50 mmol/24hr 

Source of Reference Range

Pathology Harmony recommendations

Specifications

  • EQA Status: NEQAS
  • EQAS Scheme: Yes

Related Tests

Calcium (adjusted) Creatinine Parathyroid Hormone (PTH) Phosphate (serum) Vitamin D (25-OH VitD)

Creation Date

Monday, 08 August 2011

Modification Date

Thursday, 29 December 2022

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University Hospitals Birmingham medical laboratories at Queen Elizabeth Hospital, Heartlands Hospital, Good Hope Hospital and Solihull Hospital are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Molecular Pathology is a UKAS accredited medical laboratory No. 8759
  • Biochemistry is a UKAS accredited medical laboratory No. 8910
  • Haematology and Transfusion is a UKAS accredited medical laboratory No. 8784
  • Clinical Microbiology is a UKAS accredited medical laboratory No. 8760
  • Cellular Pathology is a UKAS accredited medical laboratory No. 10141
  • Musculoskeletal laboratory is a UKAS accredited medical laboratory No. 9897
  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217.

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://qehbpathology.uk/test-database

For further information contact Louise Fallon, Quality Manager, 0121 371 5962